Phage display selection of miniprotein binders of the Estrogen Receptor.
نویسندگان
چکیده
Miniprotein phage display screening yields structured peptides with high affinity for the Estrogen Receptor (ER). Hits from apamin phage libraries feature a LXXLL motif specifically placed on the predefined miniprotein helical segment. The apamin scaffold also allows optimization of flanking amino acids to ensure an optimal ER binding affinity.
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عنوان ژورنال:
- Chemical communications
دوره 46 43 شماره
صفحات -
تاریخ انتشار 2010