Phage display selection of miniprotein binders of the Estrogen Receptor.

نویسندگان

  • Trang Phan
  • Hoang D Nguyen
  • Hülya Göksel
  • Sabine Möcklinghoff
  • Luc Brunsveld
چکیده

Miniprotein phage display screening yields structured peptides with high affinity for the Estrogen Receptor (ER). Hits from apamin phage libraries feature a LXXLL motif specifically placed on the predefined miniprotein helical segment. The apamin scaffold also allows optimization of flanking amino acids to ensure an optimal ER binding affinity.

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عنوان ژورنال:
  • Chemical communications

دوره 46 43  شماره 

صفحات  -

تاریخ انتشار 2010